ChloroquineV1, France, Analysis, bibRecord, 000271

Antiplasmodial benzophenones from the trunk latex of Moronobea coccinea (Clusiaceae).

Identifieur interne : 000271 ( France/Analysis ); précédent : 000270; suivant : 000272

Antiplasmodial benzophenones from the trunk latex of Moronobea coccinea (Clusiaceae).

Auteurs : Guillaume Marti [France] ; Véronique Eparvier [France] ; Christian Moretti [France] ; Sophie Susplugas ; Soizic Prado [France] ; Philippe Grellier [France] ; Pascal Retailleau [France] ; Françoise Guéritte [France] ; Marc Litaudon [France]

Source :

Phytochemistry [ 0031-9422 ] ; 2009-01.

RBID : Hal:hal-00373615

Abstract

In an effort to find antimalarial drugs, a systematic in vitro evaluation on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) was undertaken on sixty plant extracts collected in French Guiana. The methanol extract obtained from the latex of Moronobea coccinea exhibited a strong antiplasmodial activity (95% at 10microg/ml). The phytochemical investigation of this extract led to the isolation of eleven polycyclic polyprenylated acylphloroglucinols (PPAPs), from which eight showed potent antiplasmodial activity with IC50 ranged from 3.3microM to 37.2microM.

Url:

https://hal.archives-ouvertes.fr/hal-00373615

DOI: 10.1016/j.phytochem.2008.10.005

Affiliations:

France

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000026
to stream Hal, to step Curation: 000026
to stream Hal, to step Checkpoint: 000202
to stream Main, to step Merge: 001778
to stream Main, to step Curation: 001774
to stream Main, to step Exploration: 001774
to stream France, to step Extraction: 000271

Links to Exploration step

Hal:hal-00373615

Le document en format XML

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<author><name sortKey="Litaudon, Marc" sort="Litaudon, Marc" uniqKey="Litaudon M" first="Marc" last="Litaudon">Marc Litaudon</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-440" status="VALID">          <orgName>Institut de Chimie des Substances Naturelles</orgName>
          <orgName type="acronym">ICSN</orgName>
          <desc>            <address>              <addrLine>Avenue de la terrasse 91198 Gif sur yvette cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation name="UPR2301" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="UPR2301" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1016/j.phytochem.2008.10.005</idno>
<series><title level="j">Phytochemistry</title>
<idno type="ISSN">0031-9422</idno>
<imprint><date type="datePub">2009-01</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">              <p>In an effort to find antimalarial drugs, a systematic in vitro evaluation on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) was undertaken on sixty plant extracts collected in French Guiana. The methanol extract obtained from the latex of Moronobea coccinea exhibited a strong antiplasmodial activity (95% at 10microg/ml). The phytochemical investigation of this extract led to the isolation of eleven polycyclic polyprenylated acylphloroglucinols (PPAPs), from which eight showed potent antiplasmodial activity with IC50 ranged from 3.3microM to 37.2microM.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
</list>
<tree><noCountry><name sortKey="Susplugas, Sophie" sort="Susplugas, Sophie" uniqKey="Susplugas S" first="Sophie" last="Susplugas">Sophie Susplugas</name>
</noCountry>
<country name="France"><noRegion><name sortKey="Marti, Guillaume" sort="Marti, Guillaume" uniqKey="Marti G" first="Guillaume" last="Marti">Guillaume Marti</name>
</noRegion>
<name sortKey="Eparvier, Veronique" sort="Eparvier, Veronique" uniqKey="Eparvier V" first="Véronique" last="Eparvier">Véronique Eparvier</name>
<name sortKey="Grellier, Philippe" sort="Grellier, Philippe" uniqKey="Grellier P" first="Philippe" last="Grellier">Philippe Grellier</name>
<name sortKey="Gueritte, Francoise" sort="Gueritte, Francoise" uniqKey="Gueritte F" first="Françoise" last="Guéritte">Françoise Guéritte</name>
<name sortKey="Litaudon, Marc" sort="Litaudon, Marc" uniqKey="Litaudon M" first="Marc" last="Litaudon">Marc Litaudon</name>
<name sortKey="Moretti, Christian" sort="Moretti, Christian" uniqKey="Moretti C" first="Christian" last="Moretti">Christian Moretti</name>
<name sortKey="Prado, Soizic" sort="Prado, Soizic" uniqKey="Prado S" first="Soizic" last="Prado">Soizic Prado</name>
<name sortKey="Retailleau, Pascal" sort="Retailleau, Pascal" uniqKey="Retailleau P" first="Pascal" last="Retailleau">Pascal Retailleau</name>
</country>
</tree>
</affiliations>
</record>

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Antiplasmodial benzophenones from the trunk latex of Moronobea coccinea (Clusiaceae).

Antiplasmodial benzophenones from the trunk latex of Moronobea coccinea (Clusiaceae).

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